Abstract
to determine the structure of the unknown impurity generated during the preparation of sodium sivelestat, two new compounds, benzyl 2-(2-aminoacetamido)benzoylglycinate and benzyl (2-aminobenzoyl)glycylglycinate, were prepared, and the chemical structures were confirmed by 1H NMR, 13C NMR and MS data. The unknown impurity produced during the preparation of sodium sivelestat was finally identified as benzyl (2-aminobenzoyl)glycylglycinate, which laid the foundation for quality research on sodium sivelestat.
